Publikacije i istraživanja u vezi kurkume

Poznato je da zbog antiupalnih svojstva, kurkuma je prirodan tretman za artritis i reumatoidni artritis. Kliničke studije su takođe pokazale da kurkumin može ublažiti bolove u zglobovima, koji se javljaju kao simptomi reumatskog artritisa. Kurkumin i u ovom slučaju pokazuje efektivno delovanje na smanjenje jutarnje ukočenosti, povećanje sposobnosti dužeg hodanja i smanjenja oteklina oko zglobova.

Glaven komponente kurkuminoida su:
– kurkumin (70-75%)
– demetoksikurkumin (15-20%)
– bisdimetoksinkurkumin ( oko 3%)

Prema nekim istraživanjima, kurkumin može imati antikancerogenu, antivirusnu, i hipoholesterimičnu aktivnost, a postoje i istraživanja koja ukazuju na pozitivno dejstvo kurkumina na dijabetes melitus, kardiovaskularna i neurološka oboljenja, multiplu sklerozu, Alchajmerov bolest i reumatizam. 

Medicinska istraživanja posvećuju mnogo ozbiljniju pažnju, do današnjih dana bar 100 istraživanja su uradili i rade još uvek kako bi što bolje otkrili efekat kurkume. Klinički rezultati su obećavajući ali mora se znati da su naučna saopštenja uvek oprezna, rezultate potcenjuju. 

Postoje razna istraživanja u vezi kurkume mi ćemo samo neke navesti od tih: 

Sahdeo Prasad and Bharat B. Aggarwal. Herbal Medicine: Biomolecular and Clinical Aspects. Turmeric, the Golden Spice From Traditional Medicine to Modern Medicine. 2nd edition. Ch 13.

Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Target. 2011 Mar 1;12(3):332-47.

Lopresti AL, Maes M. Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. J Affect Disord. 2014 Oct;167:368-75. doi: 10.1016/j.jad.2014.06.001.

Akbik D, Ghadiri M, et al. Curcumin as a wound healing agent. Life Sci. 2014 Sep 6. pii: S0024-3205(14)00703-6. doi: 10.1016/j.lfs.2014.08.016.

Panchatcharam M, Miriyala S. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol Cell Biochem. 2006 Oct;290(1-2):87-96.

Kuptniratsaikul V, Dajpratham P. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014 Mar 20;9:451-8. doi: 10.2147/CIA.S58535.

Aggarwal KA et al. Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized, placebo-controlled study. 2011 Dec; 25(12):3805–10.

Rouse M, Younès A. Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity. J Endocrinol. 2014 Nov;223(2):107-17. doi: 10.1530/JOE-14-0335.

Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol. 2007;595:105-25.

Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric. J Altern Complement Med. 2003 Feb;9(1):161-8.

Chandran B1, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012 Nov;26(11):1719-25. doi: 10.1002/ptr.4639.

Pungcharoenkul K, Thongnopnua P. Effect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjects. Phytotherapy Research 2011 Nov; 25(11):1721–26.

Soni KB, Kuttan R. Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers. Indian J Physiol Pharmacol. 1992 Oct;36(4):273-5.

Liju VB, Jeena K. Gastroprotective activity of essential oils from turmeric and ginger. J Basic Clin Physiol Pharmacol. 2014 Apr 21.

Aggarawal, B, et al. “Curcumin: The Indian Solid Gold.” Advanced Experimental Medical Biology 595 (2007): 1-75.

Davis, Mark, et al. “Curcumin effects on inflammation and performance recovery following eccentric exercise induced muscle damage.” American Journal of Physiology 292.6 (2007): 2168-2173.

DeJager, Prashanti MS. Tumeric: The Ayurvedic Spice of Life (Pioneer Imprints, 2010).

Griffin, Morgan. “Vitamins and Supplements Lifestyle Guide: Turmeric (Curcumin).” Webmd. 8 DEC 2010. Web. 1 APRIL 2012.

Mercola, Joseph DO, “Super Spice Secrets: Can This Miracle Spice Stop Cancer, Alzheimer’s and Arthritis?” Mercola. 17 FEB 2009. Web. 1 APRIL 2012.

Richards, Byron CCN. “ Curcumin Helps Change Gene Function to Combat Cancer.” Wellnessresources. 12 MAY 2011. Web. 1 APRIL 2012.

Sarker, SD, et al. “Bioactivity of Turmeric, Turmeric: The genus Curcuma; Medicinal and aromatic plants-Industrial Profiles.” CRC Press, 2007.

Wargovich, Michael, et al. “Herbs Cancer Prevention and Health.” Journal of Nutrition 131.11 (2001): 3034-3036.

Weil, Andrew Dr. “Turmeric Health Benefits: Have a Happy New Year With Tumeric.” Huffingtonpost. 28 DEC 2010. Web. 1 APRIL 2012.

Wiley, Mark Dr. “Tumeric: Nature’s Powerful Anti-Inflammatory.” Healthiertalk. 10 APRIL 2011. Web. 1 APRIL 2012.

Gupta, S. et al. Curcumin, a Component of Turmeric: From Farm to Pharmacy. BioFactors (2013) 39(1):2-13

Shehzad, A. et al. Curcumin in Inflammatory Diseases. BioFactors (2013) 39(1):69-77

DiSilvestro, R. et al. Diverse effects of a low dose supplement of lapidated curcumin in healthy middle aged people. Nutrition Journal (2012) 11:79

Ramadan, G. et al. Anti-inflammatory and Anti-oxidant Properties of Curcuma longa (Turmeric) Versus Zingiber officinale (Ginger) Rhizomes in Rat Adjuvant-Induced Arthritis. Inflammation (2011) 34(4):291-301

Gupta, S. et al. Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials. The AAPS Journal (2013) 15(1): 195-218

Kertia, N. et al. Ability of Curcuminoid Compared to Diclofenac Sodium in Reducing the Secretion of Cycloxygenase-2 Enzyme by Synovial Fluid’s Monocytes of Patients with Osteoarthritis. The Indonesian Journal of Internal Medicine (2012) 105-113

White, B., Zegar-Judkins, D. et al. Does turmeric relieve inflammatory conditions?. The Journal of Family Practice (2011) 60(3):155-156

Shytle, R.D. et al. Optimized Turmeric Extract Reduces β-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer’s Transgenic Mice. Current Alzheimer Research (2012) 9, 500-506

Darvesh, A. et al. Oxidative stress and Alzheimer’s disease: dietary polyphenols as potential therapeutic agents. Expert Rev Neurother (2010) 10(5), 729-745

Kumar, K., Rai, A.K. et al. Proniosomal formulation of curcumin having anti-inflammatory and anti-arthritic activity in different experimental animal models. Pharmazie (2012) 67:825-857